https://ogma.newcastle.edu.au/vital/access/ /manager/Index en-au 5 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:43499 Wed 21 Sep 2022 10:05:07 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:23967 Wed 17 Nov 2021 16:30:14 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:21250 n = 99) and healthy controls (n = 61) were recruited. Blood was collected and spirometry was performed. The DII was calculated from food frequency questionnaires administered to study subjects. Results: The mean DII score for the asthmatics was higher than the mean DII score for healthy controls (- 1.40 vs. - 1.86, P = 0.04), indicating that their diets were more pro-inflammatory. For every 1 unit increase in DII score, the odds of having asthma increased by 70% (OR: 1.70, 95% CI: 1.03, 2.14; P = 0.040). FEV₁ was significantly associated with DII score (ß = - 3.44, 95% CI: - 6.50, - 0.39; P = 0.020), indicating that for every 1 unit increase in DII score, FEV₁ decreased by 3.44 times. Furthermore, plasma IL-6 concentrations were positively associated with DII score (ß = 0.13, 95% CI: 0.05, 0.21; P = 0.002). Conclusion and Clinical Relevance: As assessed using the DII score, the usual diet consumed by asthmatics in this study was pro-inflammatory relative to the diet consumed by the healthy controls. The DII score was associated with increased systemic inflammation and lower lung function. Hence, consumption of pro-inflammatory foods may contribute to worse asthma status, and targeting an improvement in DII in asthmatics, as an indicator of suitable dietary intake, might be a useful strategy for improving clinical outcomes in the disease.]]> Wed 11 Apr 2018 15:08:22 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:23648 Wed 11 Apr 2018 14:50:48 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:23390 Wed 11 Apr 2018 14:11:03 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:14519 Wed 11 Apr 2018 13:27:14 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:18363 Wed 11 Apr 2018 10:06:07 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:12423 Wed 11 Apr 2018 09:52:40 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:24717 50 years old; n = 45). Thirteen (36.1%) reproductive-aged females were using the OCP. Participants had induced sputum cell counts measured and blood analysed for sex hormones and inflammatory markers. Results: Obese reproductive-aged females had higher sputum %neutrophils than nonobese reproductive-aged females (45.4 ± 24.3% vs 27.5 ± 17.5%, P = 0.016); however, there was no difference in sputum neutrophils in obese compared with nonobese males (P = 0.620) or older females (P = 0.087). Multiple linear regression analysis found testosterone and OCP use to be negative predictors of sputum %neutrophils, while C-reactive protein and IL-6 were positive predictors of sputum %neutrophils. BMI and age were not significant predictors in the multivariate model. Reproductive-aged females using the OCP had significantly lower sputum %neutrophils than those not using the OCP (23.2 ± 12.6% vs 42.1 ± 23.8%, P = 0.015). Conclusions: This study suggests that sex hormones and systemic inflammation may be mediating the obese-asthma phenotype. The observation that OCP use was associated with lower sputum %neutrophils in reproductive-aged females warrants further investigation.]]> Wed 09 Mar 2022 16:03:50 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:26077 Wed 02 Mar 2022 14:25:25 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:17834 Tue 26 Jun 2018 11:21:16 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:660 Thu 25 Jul 2013 09:10:27 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:9455 Sat 24 Mar 2018 08:41:08 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:9456 0.05). There was a significant correlation between the greatest percentage fall in forced expiratory volume in 1 s (FEV₁)(r=0.6, P<0.0001), the dose–response slope (r=0.73), cumulative dose (r=0.55) and PD15 (r=0.46) for mannitol and hypertonic saline. The greatest percentage fall in FEV₁to mannitol was less in non-eosinophilic asthma. There was a lower total cell count in mannitol vs. hypertonic-saline-induced sputum. However, sputum eosinophils and neutrophils were not significantly different. Using mannitol, a higher proportion of subjects were classified as having eosinophilic asthma. There were no differences in IL-8, neutrophil elastase or matrix-metalloproteinase 9 concentrations in sputum samples induced with mannitol or hypertonic saline. Conclusion: We conclude that mannitol can be used to induce good-quality sputum, useful for analysis of inflammatory mediators and for predicting the inflammatory phenotype in asthma.]]> Sat 24 Mar 2018 08:41:08 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:2894 Sat 24 Mar 2018 08:32:49 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:2984 1 week) supplementation trials have been promising. However, the development of techniques to study isoprostanes in airway­lining fluid pave the way for further studies investigating the potential for antioxidant supplements to be used as routine therapy in asthma.]]> Sat 24 Mar 2018 08:27:56 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:12549 Sat 24 Mar 2018 08:16:34 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:13283 Sat 24 Mar 2018 08:15:15 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:10899 Sat 24 Mar 2018 08:09:04 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:20580 Sat 24 Mar 2018 07:55:36 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:21344 Sat 24 Mar 2018 07:51:24 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:21544 Sat 24 Mar 2018 07:50:26 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:29795 P<0.05) moderate-strong correlations were found between CVD-AES FAs and FA proportions in RBC membranes for EPA (r=0.62), DHA (r=0.53) and DPA (r=0.42), with a moderate correlation for LA (r=0.39) and no correlation with ALA. Significant moderate correlations were found with the AES for DHA (r=0.39), but not for LA, ALA, EPA or DPA. Conclusions: The CVD-AES provides a more accurate estimate of long chain FA intakes in hyperlipidaemic adults, compared with AES estimates. This indicates that a CVD-specific FFQ should be used when evaluating FA intakes in this population.]]> Sat 24 Mar 2018 07:30:34 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:24376 Sat 24 Mar 2018 07:16:18 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:25155 Sat 24 Mar 2018 07:14:30 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:32705 Fri 03 Dec 2021 10:33:11 AEDT ]]>